Androgen Receptor Genetic Variant Predicts COVID-19 Disease Severity: A Prospective Longitudinal Study of Hospitalized COVID-19 Male Patients.
McCoy J, Wambier CG, Herrera S, Vaño-Galván S, Gioia F, Comeche B, Ron R, Serrano-Villar S, Iwasiow RM, Tayeb MA, Cadegiani FA, Mesinkovska NA, Shapiro J, Sinclair R, Goren A.
J Eur Acad Dermatol Venereol. 2020 Sep 25. doi: 10.1111/jdv.16956. Online ahead of print.
Men infected with SARS-CoV-2 are more likely to be admitted to the intensive care unit (ICU) compared to women.(1) Previously, we have reported that among hospitalized men with COVID-19, 79% presented with androgenetic alopecia (AA) compared to 31-53% that would be expecte …
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Anti-androgens may protect against severe COVID-19 outcomes: results from a prospective cohort study of 77 hospitalized men.
Goren A, Wambier CG, Herrera S, McCoy J, Vaño-Galván S, Gioia F, Comeche B, Ron R, Serrano-Villar S, Ramos PM, Cadegiani FA, Kovacevic M, Tosti A, Shapiro J, Sinclair R.
J Eur Acad Dermatol Venereol. 2020 Sep 25. doi: 10.1111/jdv.16953. Online ahead of print.
The COVID-19 pandemic has disproportionally affected men.(1) Men infected with SARS-CoV-2 are more than twice as likely to be admitted to the intensive care unit (ICU).(2) This disparity in ICU admissions suggests the important role of androgens in COVID-19 severity …
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Male balding as a major risk factor for severe COVID-19: a possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals.
Wambier CG, McCoy J, Goren A.
J Am Acad Dermatol. 2020 Sep 11:S0190-9622(20)32600-1. doi: 10.1016/j.jaad.2020.09.015. Online ahead of print.
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Androgen sensitivity in COVID-19 and antiandrogens: Prospective data are still needed.
Ianhez M, Ramos PM, Goren A, Miot HA.
Dermatol Ther. 2020 Aug 9:e14166. doi: 10.1111/dth.14166. Online ahead of print.
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Are night shift workers at an increased risk for COVID-19?
Lim RK, Wambier CG, Goren A.
Med Hypotheses. 2020 Jul 29;144:110147. doi: 10.1016/j.mehy.2020.110147. Online ahead of print.
Recent data has revealed an association between coronavirus disease-19 (COVID-19) incidence and seasonally regulated androgen sensitivity. This potential relationship between SARS-CoV-2 infection and clock genes, coupled with previously reported effects of night shift work …
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Androgenetic alopecia in COVID-19: compared to age-matched epidemiologic studies and hospital outcomes with or without the Gabrin sign.
Wambier CG, Vaño-Galván S, McCoy J, Pai S, Dhurat R, Goren A.
J Am Acad Dermatol. 2020 Jul 28:S0190-9622(20)32300-8. doi: 10.1016/j.jaad.2020.07.099. Online ahead of print.
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Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19.
Cadegiani FA, Wambier CG, Goren A.
Front Med (Lausanne). 2020 Jul 28;7:453. doi: 10.3389/fmed.2020.00453. eCollection 2020.
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Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).
Cadegiani FA, Goren A, Wambier CG.
Med Hypotheses. 2020 Jul 16;143:110112. doi: 10.1016/j.mehy.2020.110112. Online ahead of print.
In coronavirus disease-19 (COVID-19), four major factors have been correlated with worse prognosis: aging, hypertension, obesity, and exposure to androgen hormones. ...Hence, spironolactone may provide protection from SARS-CoV-2, and has sufficient plausibility to be clini …
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Clock genes may drive seasonal variation in SARS-CoV-2 infectivity: are we due for a second wave of COVID-19 in the fall?
Goren A, Wambier CG, McCoy J, Shapiro J, Vaño-Galván S, Herrera S, Glode LM.
J Biol Regul Homeost Agents. 2020 Jul 16;34(4). doi: 10.23812/20-359-L-35. Online ahead of print.
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Safety Measures in Dermatology Help Minimize Spread of COVID-19.
Goren A, Rathod D, Kroumpouzos G, Jafferany M, Goldust M.
Dermatol Ther. 2020 Jun 7. doi: 10.1111/dth.13773. Online ahead of print.
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Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients - the "Gabrin sign".
Wambier CG, Vaño-Galván S, McCoy J, Gomez-Zubiaur A, Herrera S, Hermosa-Gelbard Á, Moreno-Arrones OM, Jiménez-Gómez N, González-Cantero A, Pascual PF, Segurado-Miravalles G, Shapiro J, Pérez-García B, Goren A.
J Am Acad Dermatol. 2020 May 21:S0190-9622(20)30948-8. doi: 10.1016/j.jaad.2020.05.079. Online ahead of print.
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Androgen sensitivity gateway to COVID-19 disease severity.
Wambier CG, Goren A, Vaño-Galván S, Ramos PM, Ossimetha A, Nau G, Herrera S, McCoy J.
Drug Dev Res. 2020 May 15:10.1002/ddr.21688. doi: 10.1002/ddr.21688. Online ahead of print.
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Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19?
McCoy J, Wambier CG, Vano-Galvan S, Shapiro J, Sinclair R, Müller Ramos P, Washenik K, Andrade M, Herrera S, Goren A.
J Cosmet Dermatol. 2020 Apr 25:10.1111/jocd.13455. doi: 10.1111/jocd.13455. Online ahead of print.
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A preliminary observation: Male pattern hair loss among hospitalized COVID-19 patients in Spain - A potential clue to the role of androgens in COVID-19 severity.
Goren A, Vaño-Galván S, Wambier CG, McCoy J, Gomez-Zubiaur A, Moreno-Arrones OM, Shapiro J, Sinclair RD, Gold MH, Kovacevic M, Mesinkovska NA, Goldust M, Washenik K.
J Cosmet Dermatol. 2020 Apr 16. doi: 10.1111/jocd.13443. Online ahead of print.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated.
Wambier CG, Goren A.
J Am Acad Dermatol. 2020 Apr 10:S0190-9622(20)30608-3. doi: 10.1016/j.jaad.2020.04.032. Online ahead of print.
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What does androgenetic alopecia have to do with COVID-19? An insight into a potential new therapy.
Goren A, McCoy J, Wambier CG, Vano-Galvan S, Shapiro J, Dhurat R, Washenik K, Lotti T.
Dermatol Ther. 2020 Apr 1:e13365. doi: 10.1111/dth.13365. Online ahead of print.
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